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ALL References

Parasym Plus References:

Acetyl-L-carnitine as a precursor of acetylcholine. PMID: 2215852

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen. PMID: 23929694

Potential therapeutic targets of huperzine A for Alzheimer’s disease and vascular dementia. PMID: 18565502

Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. PMID: 17657601

Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. PMID: 17056129

Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine PMID: 16364207

The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. PMID: 16697744  

The vagus nerve and the inflammatory reflex: wandering on a new treatment paradigm for systemic inflammation and sepsis. PMID: 22913335

The clinical importance of the anti-inflammatory vagovagal reflex. PMID: 24095121

Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. PMID : 2585551

Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines. PMID: 7500384  

Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. PMID: 1662399

Carnitine biosynthes A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers. PMID: 1428296

 

Digestive Enzymes References:

Pathophysiology of gastro-esophageal reflux disease: a role for mucosa integrity? (Farre R 2013)


Utilising polyphenols for the clinical management of Candida albicans biofilms (Shahzad M 2014)


Long-term lansoprazole control of gastric acid and pepsin secretion in ZE and non-ZE hypersecretors: a prospective 10-year study (Hirschowitz et al 2001)


The role of pepsin in acid injury to esophageal epithelium (Tobey et al 2001)


Role of FODMAPs in patients with irritable bowel syndrome: A review (Mansueta et al 2015)


Inulin-type prebiotics – a review (Kelly G 2008)


Pancreatic enzyme replacement therapy in chronic pancreatitis (Sikkens et al 2010)

 

Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery (Domingues-Munoz JE 2009)

 

Putative role of beta-1,3glucans in Candida albicans biofilm resistance (Nett et al 2007)


Compounds active against cell walls of medically important fungi (Hector RF 1993)


Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review (Mudgil D 2013)


The role of enzyme supplementation in digestive disorders (Roxas M 2008)


Candida albicans and Enterocococcusfaecalis in the gut: synergy in commensalism? (Garsin DA et al 2013)


Beta-Glucan of Candida albicans cell wall causes the subversion of human monocyte differentiation into dendritic cells (Nisini R et al 2007)


The cell wall: a carbohydrate armor for the fungal cell (Latge JP 2007)


Antifungal activity of black tea polyphenols (catechins and theaflavins) against Candida species (Sitheeque MA et al 2009)


Anti-inflammatory, antioxidant and antifungal activity of Chuquiragaspinose (Casado R et al 2011)

 

Soothing Digestive Aid References:

Haniadka R et al. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct. 2013 Jun;4(6):845-55.


Gorbach S. Microbiology of the Gastrointestinal Tract. Ch. 95
Wu KL, et al. Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol. 2008 May;20(5):436-40.


Gastrointestinal motility enhancing effect of ginger and its active constituents (Yamahara J 1990)


Gupta YK, Sharma M. Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale). Methods Find Exp Clin Pharmacol. 2001 Nov;23(9):501-3.


Yamahara J. Gastrointestinal motility enhancing effect of ginger and its constituents. Chem Pharm Bull. 1990 Feb;38(2):430-1

 

Johnston CS, Gaas CA. Vinegar: Medicinal Uses and Antiglycemic Effect. Medscape General Medicine. 2006;8(2):61.


Wang Z, Hasegawa J, Wang X, et al. Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats. Yonago Acta medica. 2011;54(1):11-19.


LEE, H., SEO, E., KANG, N. and KIM, W. (2008). [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. The Journal of Nutritional Biochemistry, 19(5), pp.313-319.


KONDO, T., KISHI, M., FUSHIMI, T., UGAJIN, S. and KAGA, T. (2009). Vinegar Intake Reduces Body Weight, Body Fat Mass, and Serum Triglyceride Levels in Obese Japanese Subjects. Bioscience, Biotechnology, and Biochemistry, 73(8), pp.1837-1843.


Pohl, D., Fox, M., Fried, M., Göke, B., Prinz, C., Mönnikes, H., Rogler, G., Dauer, M., Keller, J., Lippl, F., Schiefke, I., Seidler, U. and Allescher, H. (2008). Do We Need Gastric Acid?. Digestion, 77(3-4), pp.184-197.

 

Haniadka, R., Saldanha, E., Sunita, V., Palatty, P., Fayad, R. and Baliga, M. (2013). A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food & Function, 4(6), p.845.


Chen, B., Wu, P., Chen, K., Fu, T., Wang, H. and Chen, C. (2009). Antiallergic Potential on RBL-2H3 Cells of Some Phenolic Constituents of Zingiber officinale(Ginger). Journal of Natural Products, 72(5), pp.950-953.


Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. International Journal of Preventive Medicine. 2013;4(Suppl 1):S36-S42.


Shukla, Y. and Singh, M. (2007). Cancer preventive properties of ginger: A brief review. Food and Chemical Toxicology, 45(5), pp.683-690.


Dugasani, S., Pichika, M., Nadarajah, V., Balijepalli, M., Tandra, S. and Korlakunta, J. (2010). Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology, 127(2), pp.515-520.


Tjendraputra, E., Tran, V., Liu-Brennan, D., Roufogalis, B. and Duke, C. (2001). Effect of Ginger Constituents and Synthetic Analogues on Cyclooxygenase-2 Enzyme in Intact Cells. Bioorganic Chemistry, 29(3), pp.156-163.


Wu, K., Rayner, C., Chuah, S., Changchien, C., Lu, S., Chiu, Y., Chiu, K. and Lee, C. (2008). Effects of ginger on gastric emptying and motility in healthy humans. European Journal of Gastroenterology & Hepatology, 20(5), pp.436-440.


Johnston, C., Steplewska, I., Long, C., Harris, L. and Ryals, R. (2010). Examination of the Antiglycemic Properties of Vinegar in Healthy Adults. Annals of Nutrition and Metabolism, 56(1), pp.74-79.


YAMAHARA, J., HUANG, Q., LI, Y., XU, L. and FUJIMURA, H. (1990). Gastrointestinal motility enhancing effect of ginger and its active constituents. CHEMICAL & PHARMACEUTICAL BULLETIN, 38(2), pp.430-431.


Nicoll, R. and Henein, M. (2009). Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease?. International Journal of Cardiology, 131(3), pp.408-409.

 

Heimes, K., Feistel, B. and Verspohl, E. (2009). Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts. European Journal of Pharmacology, 624(1-3), pp.58-65.


Aggarwal, B. and Shishodia, S. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical Pharmacology, 71(10), pp.1397-1421.


Yk, G. and M, S. (2017). Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale). – PubMed – NCBI. [online] Ncbi.nlm.nih.gov. Available at: https://www.ncbi.nlm.nih.gov/pubmed/11876024 [Accessed 21 Nov. 2017].


Beasley, D., Koltz, A., Lambert, J., Fierer, N. and Dunn, R. (2015). The Evolution of Stomach Acidity and Its Relevance to the Human Microbiome. PLOS ONE, 10(7), p.e0134116.


Lu, Y. and Owyang, C. (2017). Duodenal acid-induced gastric relaxation is mediated by multiple pathways. [online] Gastrointestinal and Liver Physiology. Available at: https://ajpgi.physiology.org/content/276/6/G1501 [Accessed 21 Nov. 2017].

 

Thera pH References:

Barcelo, P, et al. “Randomized Double-Blind Study of Potassium Citrate in Idiopathic Hypocitraturic Calcium Nephrolithiasis.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Dec. 1993, www.ncbi.nlm.nih.gov/pubmed/8230497.

Curhan, G C, et al. “A Prospective Study of the Intake of Vitamins C and B6, and the Risk of Kidney Stones in Men.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, June 1996, www.ncbi.nlm.nih.gov/pubmed/8618271.

Curhan, G C, et al. “Intake of Vitamins B6 and C and the Risk of Kidney Stones in Women.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Apr. 1999, www.ncbi.nlm.nih.gov/pubmed/10203369.

Eisner, B H, et al. “High Dietary Magnesium Intake Decreases Hyperoxaluria in Patients with Nephrolithiasis.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Oct. 2012, www.ncbi.nlm.nih.gov/pubmed/22921695.

Ettinger, B, et al. “Potassium-Magnesium Citrate Is an Effective Prophylaxis against Recurrent Calcium Oxalate Nephrolithiasis.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Dec. 1997, www.ncbi.nlm.nih.gov/pubmed/9366314.

Kato, Y, et al. “Changes in Urinary Parameters after Oral Administration of Potassium-Sodium Citrate and Magnesium Oxide to Prevent Urolithiasis.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Jan. 2004, www.ncbi.nlm.nih.gov/pubmed/14751336.

Lindberg, J, et al. “Effect of Magnesium Citrate and Magnesium Oxide on the Crystallization of Calcium Salts in Urine: Changes Produced by Food-Magnesium Interaction.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Feb. 1990, www.ncbi.nlm.nih.gov/pubmed/2299712.

Massey, L. “Magnesium Therapy for Nephrolithiasis.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, June 2005, www.ncbi.nlm.nih.gov/pubmed/16100850.

Ortiz-Alvarado, O, et al. “Pyridoxine and Dietary Counseling for the Management of Idiopathic Hyperoxaluria in Stone-Forming Patients.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, May 2011, www.ncbi.nlm.nih.gov/pubmed/21334732.

Pak, C Y, et al. “Physicochemical Action of Potassium-Magnesium Citrate in Nephrolithiasis.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Mar. 1992, www.ncbi.nlm.nih.gov/pubmed/1585829.

Rao, T. V. R. K., and V. K. Choudhary. Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, July 2005, www.ncbi.nlm.nih.gov/pmc/articles/PMC3453845/.

Rattan, V, et al. “Effect of Combined Supplementation of Magnesium Oxide and Pyridoxine in Calcium-Oxalate Stone Formers.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/7992461.

Reddy, S.V. Krishna, et al. Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, June 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4064051/.

Robinson, M R, et al. “Impact of Long-Term Potassium Citrate Therapy on Urinary Profiles and Recurrent Stone Formation.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Mar. 2009, www.ncbi.nlm.nih.gov/pubmed/19152932.

Sakhaee, K, et al. “Contrasting Effects of Various Potassium Salts on Renal Citrate Excretion.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Feb. 1991, www.ncbi.nlm.nih.gov/pubmed/1899422.

Zimmermann, D J, et al. “Importance of Magnesium in Absorption and Excretion of Oxalate.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/15812215.

 

NAC MAX References:

“Acetylcysteine (By Breathing) – National Library of Medicine – PubMed Health.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0008809/.

Bueche, Celine Zoe, et al. Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3661381/.

Deepmala, et al. “Clinical Trials of N-Acetylcysteine in Psychiatry and Neurology: A Systematic Review.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Aug. 2015, www.ncbi.nlm.nih.gov/pubmed/25957927.

Eakin, Katharine, et al. “Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury.” PLOS ONE, Public Library of Science, journals.plos.org/plosone/article?id=10.1371/journal.pone.0090617.

Grinberg, L, et al. “N-Acetylcysteine Amide, a Novel Cell-Permeating Thiol, Restores Cellular Glutathione and Protects Human Red Blood Cells from Oxidative Stress.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, 1 Jan. 2005, www.ncbi.nlm.nih.gov/pubmed/15589382.

Hara, Y, et al. “Evaluation of the Neuroprotective Potential of N-Acetylcysteine for Prevention and Treatment of Cognitive Aging and Dementia.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/29182711.

Mokhtari, Vida, et al. Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/.

Monti, Daniel A., et al. “N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson’s Disease: Preliminary Clinical and Cell Line Data.” PLOS ONE, Public Library of Science, journals.plos.org/plosone/article?id=10.1371/journal.pone.0157602.

Oliver, G, et al. “N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: a Systematic Review.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, 30 Apr. 2015, www.ncbi.nlm.nih.gov/pubmed/25912534.

Shahripour, Reza Bavarsad, et al. Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Mar. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC3967529/.

What our Customers are Saying About Us

Parasym Plus has Changed My Life - REALLY!

Wow! What a difference! I have to take two doses a day because my vagus nerve is not working well! I can tell because I tend to have a fast heart rate AND constipation. It helps me swallow easier. And my salivary glands are working! No more dry eyes or dry mouth. It helps my cognition, my gut, and my emotions. This one is worth it!!

~ Susan G.

Much Better Digestion Now

Digestive Enzymes has been a good one for me. My husband and I both take this daily now. I’ve combined this with Parasym Plus and now have regular DAILY (woohoo) bowel movements. Sounds like a small thing but those of us with GI issues can appreciate how much of a relief this is. Thanks for this!

~ Lopez

Much, much, better!

I couldn’t believe how much better my daughter is! She is on the spectrum, and has had difficulty just doing life! Just one week after starting NAC MAX, she was able to look me right in the eye and she felt like she was fitting in better at school. It has been two months now, and she is dating and doing things with her friends. I can’t tell you what it means to me to see her come back to us. Thank you!

~ Abigail S.

Doctor recommended for Diamox

This is what my doctor recommended for me when I began taking Diamox for IIH! She told me to minimize my salt intake, enjoy lemon juice whenever possible, and take Thera pH with every dose of Diamox to help prevent kidney stones. So far, so good!

-Michael D.

Best digestive aid I have tried

I’ve been taking The Soothing Digestive Aid for at least 6 months now. Of all the supplements I’ve used to improve my digestion it works the best. I take 1 capsule at the beginning of each meal. The important part is remembering to take some pills with me when I eat out. I can tell the difference when I don’t have it.

~ Jen W.

Commitment to Quality

At TJ Nutrition®, We Have An Unwavering Commitment To Quality

We always go beyond the FDA’s required product testing to ensure you receive the highest quality supplement possible. Our manufacturing facilities are third party certified by industry watchdog organizations such as NSF and NPA, which means they have been strictly audited for compliance with Good Manufacturing Practices (GMP’s).

Money Back Guarantee

TJ Nutrition’s® goal is 100% customer satisfaction – which is why we offer a 30-day money-back guarantee. If within 30 days you decide any of our products are not for you, we will gladly refund your money.